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. 2022 Mar 8;27:24. doi: 10.1186/s11658-022-00321-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — TMEM43 expression is upregulated and associated with poor survival in pancreatic cancer. A TMEM43 mRNA expression levels in different tumor samples and the corresponding normal samples (http://gepia.cancer-pku.cn/). B Western blotting and immunohistochemistry (IHC) assays showed the expression levels of TMEM43 in pancreatic cancer tissue samples and matched normal samples (n = 5). Scale bar (left) = 500 μm, scale bar (right) = 50 μm. C IHC showing the expression of TMEM43 in pancreatic cancer tissues and normal tissues in TMA cohort 1. Scale bar (left) = 200 μm, scale bar (right) = 50 μm. D Kaplan–Meier curve analysis showing the association of TMEM43 protein expression levels with patient survival using pancreatic cancer TMA cohort 2. E, F Kaplan–Meier curve analysis showing the correlation of TMEM43 mRNA levels with survival using the TCGA dataset. G, H Univariate and multivariate Cox regression analyses were performed in the TCGA pancreatic cancer dataset. *P < 0.05