Fig. 1.

LAGE3 was upregulated in HCC and correlated with poor overall survival. A LAGE3 expression in HCC. TPM, transcripts per million. B Overall survival of HCC patients with high LAGE3 expression. HR, hazard ratio. C Expression of LAGE3 mRNA in four HCC cell lines (Huh7, Hep3B, SK-HEP1, and HCC-LM3 cells). D Relative expression of LAGE3 in Hep3B cells transfected with LAGE3-OE. E Effects of four different siRNA sequences targeting LAGE3 on its gene expression in SK-HEP1 cells. F Western blot bands of LAGE3 in Hep3B cells transfected with LAGE3-OE or SK-HEP1 cells transfected with LAGE3 siRNAs. Data are shown as mean ± standard deviation. *p < 0.05, **p < 0.01