Fig. 4.
LAGE3 promoted the in vivo growth and suppressed the apoptosis of HCC tumor cells. Mice were subcutaneously injected with 2 × 106 Hep3B or SK-HEP1 cells, followed by injection with 10 μg of LAGE3-OE or LAGE3 shRNA plasmid three times a week for four week. A Volume of tumors. B mRNA and protein expression of LAGE3 in tumors. C Expression of LAGE3 and Ki67 was evaluated by immunohistochemistry. D TUNEL staining of late apoptotic cells. Data are shown as mean ± standard deviation. *p < 0.05, **p < 0.01