Fig. 5.

The LPA release-activated RAGE-PI3K/AKT signaling was responsible for mesothelial cell-mediated malignancy in ovarian cancer cells. A, B Following treatment with exogenous LPA, the activation of RAGE-PI3K/AKT signaling was determined in ovarian cancer cells under CM and acacetin conditions. Quantification of the above bands was analyzed by Image J software. C–F The subsequent effects on cell proliferation (C), invasion (D), the transcripts (E) and production (F) of IL-6 and IL-8were further determined. *P < 0.05 vs. control group, ^#P < 0.05 vs. CM-treated group, ^&P < 0.05 vs. CM-Aca group