Table 3.
Diagnostic efficiency of cerebrospinal fluid biomarkers
| Parameters | All patients | EVD-related infections | ||||
|---|---|---|---|---|---|---|
| HBP (ng/mL) | Procalcitonin (ng/mL) | Lactate (mmol/L) | HBP (ng/mL) | Procalcitonin (ng/mL) | Lactate (mmol/L) | |
| Cutoff level | > 23 | > 0.09 | > 3.9 | > 21 | > 0.09 | > 3.9 |
| Sensitivity (%) | 97 | 53 | 92 | 100 | 54 | 88 |
| Specificity (%) | 95 | 90 | 98 | 96 | 89 | 100 |
| Positive predictive value (%) | 93 | 78 | 97 | 100 | 54 | 88 |
| Negative predictive value (%) | 98 | 74 | 94 | 95 | 87 | 100 |
CSF cerebrospinal fluid. HBP heparin-binding protein. EVD-related infections external ventricular drainage-related infections