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. 2022 Jan 29;17:1. doi: 10.1186/s12263-022-00704-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Per-allele estimates for hazards ratio (HR) of clinical endpoints driven by genetic vitamin D exposure in hypertensive-diabetic subjects. A Per-allele prediction estimates of candidate/constituent vitamin D genetic variants, or their combinations for combined cardiovascular (CV) endpoints are as follows: rs2060793: (HR = 0.98 [95%CI 0.86 to 1.12], P = 0.75); rs1993116: (HR = 0.98 [95%CI 0.86 to 1.11], P = 0.75); rs2282679: (HR = 0.83 [95%CI 0.73 to 0.95], P = 0.005); rs4588: (HR = 0.83 [95%CI 0.73 to 0.94], P = 0.004); rs1155563: (HR = 0.89 [95%CI 0.79 to 1.01], P = 0.070); rs7041: (HR = 0.82 [95%CI 0.72 to 0.94], P = 0.003); rs4588+rs7041: (HR = 0.87 [95%CI 0.81 to 0.94], P = 0.001); rs2060793+rs7041: (HR = 0.90 [95%CI 0.82 to 0.98], P = 0.020); rs2060793+rs4588: (HR= 0.90 [95%CI 0.82 to 0.99], P=0.024); rs2060793+rs4588+rs7041: (HR = 0.90 [95%CI 0.84 to 0.96], P = 0.002). The estimates were derived from multivariable Cox-proportional hazards model with adjustment for potential confounders as illustrated in Supplementary Table 1 (Multivariable Model 1).B Per-allele prediction estimates of candidate/constituent vitamin D genetic variants, or their combinations for incident myocardial infarction are as follows: rs2060793: (HR = 0.89 [95%CI 0.69 to 1.15], P = 0.38); rs1993116: (HR = 0.89 [95%CI 0.69 to 1.15], P = 0.36); rs2282679: (HR = 0.80 [95%CI 0.63 to 1.02], P = 0.07); rs4588: (HR = 0.82 [95%CI 0.64 to 1.04], P = 0.10); rs1155563: (HR = 0.90 [95%CI 0.71 to 1.14], P = 0.40); rs7041: (HR = 0.66 [95%CI 0.50 to 0.87], P = 0.003); rs4588+rs7041: (HR = 0.81 [95%CI 0.70 to 0.94], P = 0.005); rs2060793+rs7041: (HR = 0.77 [95%CI 0.64 to 0.92], P = 0.005); rs2060793+rs4588: (HR = 0.85 [95%CI 0.72 to 1.02], P = 0.08); rs2060793+rs4588+rs7041: (HR = 0.83 [95%CI 0.73 to 0.94], P = 0.004). The estimates were derived from multivariable Cox-proportional hazards model with adjustment for potential confounders (including age, diabetes mellitus, body-mass index, use of lipid-lowering drugs and creatinine), similar to multivariable model 1 illustrated in Supplementary Table 1