Table 1.

Derivation and hypertensive-diabetic subcohort sample characteristics, stratified by incident combined cardiovascular (CV) endpoints

	Derivation Subcohort	Hypertensive-Diabetic Subcohort
	(i) N = 1460	Nil incident event (ii) N = 3185	Incident CV endpoints(iii) N = 561
Male [n (%)]	786 (53.8%)	1993 (62.6%)	354 (63.1%)	< 0.001*	0.81
Age (years)	56.2 ± 11.4	64.7 ± 11.5	71.8 ± 10.4	< 0.001*	< 0.001*
Ever smoking [n (%)]	504 (34.5%)	1167 (36.6%)	239 (42.6%)	0.001*	0.007*
Body mass index (kgm-2)	24.0 ± 3.5	25.9 ± 4.1	25.9 ± 4.4	< 0.001*	0.89
Diabetes mellitus [n (%)]	473 (32.4%)	2485 (78.0%)	469 (83.6%)	< 0.001*	0.003*
Systolic blood pressure (mmHg)	120.0 ± 14.8	139.3 ± 19.4	141.4 ± 21.9	< 0.001*	0.031*
Diastolic blood pressure (mmHg)	72.1 ± 8.8	75.5 ± 11.0	70.1 ± 11.3	< 0.001*	< 0.001*
LDL-cholesterol (mmol/L)	3.1 ± 0.9	2.6 ± 0.9	2.5 ± 1.0	< 0.001*	0.077
HDL-cholesterol (mmol/L)	1.4 ± 0.5	1.24 ± 0.44	1.17 ± 0.33	< 0.001*	< 0.001*
Triglycerides (mmol/L)	1.4 ± 1.0	1.6 ± 1.1	1.6 ± 1.2	< 0.001*	0.66
Fasting glucose (mmol/L)	6.8 ± 9.0	7.5 ± 6.3	8.5 ± 10.5	0.001*	0.037*
Creatinine (μmol/L)	79.8 ± 50.1	98.4 ± 74.6	136.6 ± 113.1	< 0.001*	< 0.001*
Lipid-lowering therapy [n (%)]	849 (58.2%)	2254 (70.8%)	452 (80.6%)	< 0.001*	< 0.001*
25-hydroxyvitamin D (Ln) ‡	3.02 ± 0.33	3.01 ± 0.33	2.98 ± 0.38	0.035*	0.043*
Season of recruitment				0.57	0.61
Spring [n (%)]	225 (15.4%)	515 (16.2%)	88 (15.7%)
Summer [n (%)]	478 (32.7%)	940 (29.5%)	178 (31.7%)
Autumn [n (%)]	222 (15.2%)	537 (16.9%)	99 (17.6%)
Winter [n (%)]	535 (36.6%)	1193 (37.5%)	196 (34.9%)
Vitamin D GRS ⌞	2.7 ± 1.2	2.7 ± 1.2	2.5 ± 1.3	0.001*	0.002*

*P < 0.05

^†P value 1: Group (iii) versus (i)

P value 2: Group (iii) versus (ii)

^‡Natural log-transformed due to skewed distribution

^⌞GRS, genetic risk score (linear 0-6) based on allele scoring summation (CYP2R1: rs2060793; GC: rs4588, rs7041)