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. 2022 Jan 24;27:8. doi: 10.1186/s11658-022-00306-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The JAK-STAT pathway is regulated by β3GNT2 in ESCA. A GSEA plot showing a positive correlation between β3GNT2 expression and the JAK-STAT pathway. B Heatmap showing the Spearman correlation coefficient between β3GNT2 and the JAK-STAT pathway-related genes in ESCA. Asterisks represent the significance of the Spearman correlation. C Analysis of the JAK-STAT pathway-related protein expression by Western blot. D–G The effect of ruxolitinib on cell proliferation, colony formation, migration, and invasion was determined by CCK-8 assay (D), colony formation assay (E), Transwell migration assay (F), and Matrigel invasion assay (G). Cells were transfected with the indicated plasmids. shNC, negative control shRNA; shRNA, β3GNT2 shRNA2 lentiviral vector; Mock, empty plasmid; OV, pcDNA3.1/β3GNT2 plasmid. Data are expressed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001