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. 2022 Feb 17;23(1):26. doi: 10.1186/s10194-022-01394-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — 5-HT_1B/D/F receptors co-staining with CGRP. CGRP-ir revealed a vesicular staining pattern in neuron cell bodies and C-fibres. A CGRP co-localized with 5-HT_1B receptors in some neuron cell bodies (Arrowhead). No expression of the 5-HT_1B receptor was observed in CGRP positive C-fibres. Insert: CGRP immunoreactive C-fibre adjacent to 5-HT_1B positive neuron cell body. Arrow marks a visible C-fibre bouton. B CGRP-ir co-localized with 5-HT_1D in neuron cell bodies (Arrowhead). No expression of the 5-HT_1D receptor was detected in the CGRP immunoreactive C-fibres. Insert: CGRP positive C-fibre intermingled between 5-HT_1D positive Aδ-fibres. Arrow marks a visible C-fibre bouton. C CGRP co-localized with weakly positive 5-HT_1F receptors in neuron somas. No expression of the 5-HT_1F receptor was detected in C-fibres. Insert: CGRP positive C-fibre in proximity to 5-HT_1F positive neuron cell bodies. Arrow marks a visible C-fibre bouton