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21.31 full factorial design variables and constraints.
| Independent variables | Levels | |||
|---|---|---|---|---|
| −1 | 0 | +1 | Constrains | |
| X1: phospholipid type | PDC | – | PDS | In range |
| X2: SC concentration | 0.1% | 0.3% | 0.6% | In range |
| Dependent variables | ||||
| R1: EE (%) | Maximize | |||
| R2: ZP (mV) | Maximize | |||
| R3: PS (nm) | Minimize | |||
PDC: phosphatidyl choline; PDS: phosphatidyl serine; SC: sodium cholate; EE%: entrapment efficiency; ZP: zeta potential; PS: particle size.
