Table 1. Potency and isoform selectivity of NBI-921352 for human and mouse Na_V channels.

Note that IC₅₀s for the neuronal sodium channels, Na_V 1.1, Na_V 1.2, and Na_V1.6, have been more accurately defined than those for non-neuronal sodium channels. Explicit IC₅₀’s for Na_V1.3, Na_V1.4, and Na_V1.5 were not determined since the inhibition at the highest concentration tested (30 µM) was <50%. IC₅₀’s are the mean of 3 separate biological replicates of the IC₅₀ determinations for each channel. The error is shown as the 95% confidence interval of the mean IC₅₀. None of the other tested isoforms displayed IC₅₀’s within the 95% confidence interval of the Na_V1.6 IC₅₀ and the confidence intervals were well separated as well.

	NaV1.6	NaV1.1	NaV1.2	NaV1.3	NaV1.4	NaV1.5	NaV1.7
Human IC50 (µM)	0.051	39	6.9	> 30	> 30	> 30	14
95% CI	0.030–0.073	31–47	1.6–12	-	-	-	6.4–22
Human Selectivity hNaV1.X / hNaV1.6	1	756	134	> 583	> 583	> 583	276
Mouse IC50 (µM)	0.058	41	11
Mouse Selectivity mNaV1.X / mNaV1.6	1	709	191