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Attenuation of neurovirulence of CL3-Luc by truncation of ORF 212. (A) BALB/c mice were injected i.c. with 106 PFU of the indicated viruses. Virus replication was determined by bioluminescence as described for Fig. 7. (B) Total photon flux of animals shown in panel A. Bars indicate arithmetic means ± SD. ***, P < 0.001. Significance was calculated using Mann-Whitney test. This experiment was repeated with essentially the same result.
