Table 3.
Geometric mean titer (GMT)/concentration (GMC) of enterovirus 71 (EV71), measles, mumps, rubella, and Japanese encephalitis (JE) antibody pre and post vaccination, per-protocol sets
| Group 1 |
Group 2 or Group 3 |
||
|---|---|---|---|
| Variable | GMT/GMC (95% CI) | GMT/GMC (95% CI) | P value |
| EV71 neutralizing antibody (N) | 110 | 112 | |
| Pre-vaccination GMT | 4.13 (4.00,4.27) | 4.18 (4.03,4.33) | .539 |
| Post-vaccination GMT | 96.86 (75.67,123.99) | 101.25 (78.22,131.06) | .901 |
| Measles IgG antibody (N) | 110 | 116 | |
| Pre-vaccination GMC | 35.49 (32.24,39.06) | 38.39 (35.44,41.57) | .087 |
| Post-vaccination GMC | 2982.53 (2545.55,3494.53) | 2797.91 (2371.76,3300.64) | .260 |
| Mumps IgG antibody (N) | 110 | 116 | |
| Pre-vaccination GMC | 30.85 (28.03,33.95) | 30.27 (27.40,33.43) | .703 |
| Post-vaccination GMC | 532.63 (457.18,620.53) | 424.89 (367.10,491.78) | .035 |
| Rubella IgG antibody (N) | 110 | 116 | |
| Pre-vaccination GMC | 2.62 (2.45,2.80) | 2.89 (2.65,3.15) | .146 |
| Post-vaccination GMC | 79.56 (68.58,92.30) | 75.70 (66.16,86.61) | .415 |
| Japanese encephalitis neutralizing antibody (N) | 110 | 116 | |
| Pre-vaccination GMT | 2.60 (2.52,2.68) | 2.55 (2.49,2.60) | .273 |
| Post-vaccination GMT | 7.12 (6.32,8.01) | 7.33 (6.55,8.20) | .688 |
Study groups were as follows: simultaneous receipt of enterovirus 71 (EV71) vaccine (dose 1) and measles-mumps-rubella vaccine (MMR) on d 0 and EV71 vaccine (dose 2) and live-attenuated Japanese encephalitis vaccine (LA-JEV) on d 30 (Group 1); receipt of MMR and LA-JEV on d 0 and 30, respectively (Group 2); or receipt of doses 1 and 2 of EV71 vaccine on d 0 and 30, respectively (Group 3). GMT: geometric mean titer; GMC: geometric mean concentration.