Table 3.

(a) Proportion of Guillain-Barré syndrome (GBS) inpatient admissions (IP) over all admissions, and (b) Proportion of negative control diagnoses (dx) inpatient admissions over all admissions, using MarketScan Commercial Claims and Encounters (CCAE) (18–64 years) and Centers for Medicare and Medicaid Services (CMS) (≥65 years) Medicare data, United States, 2010–2018^a

		Risk window			Primary control window					Secondary control window
		(1–42 days after HZ)			(100–365 days after HZ)					(43–99 days after HZ)
Age (years)	N (persons)	# IP	# GBS IP/ Negative control dx	% GBS IP	# IP	# GBS IP	% GBS IP	Relative Risk (95% CI)	p-Value	# IP	# GBS IP	% GBS IP	Relative Risk (95% CI)	p-Value
(a) Risk of GBS: GBS in cohort as proportion of all inpatient admissions
18–64	30,748	5,932	6	0.10%	29,458	8	0.03%	3.72 (1.12–12.45)	.0325	6,273	1	0.02%	6.35 (0.73–55.46)	.0946
≥65	140,619	36,541	22	0.06%	165,386	34	0.02%	2.93 (1.44–5.94)	.0029	34,255	20	0.06%	1.03 (0.52–2.05)	.9299
(b) Risk of selected negative controls: Negative control diagnoses in cohort as proportion of all inpatient admissions
18–64, Appendicitis	30,748	5,932	41	0.69%	29,458	206	0.70%	0.99 (0.70–1.39)	.9465	6,273	41	0.65%	1.06 (0.68–1.64)	.8019
18–64, Nephrolithiasis	30,748	5,932	29	0.49%	29,458	179	0.61%	0.80 (0.52–1.25)	.3309	6,273	30	0.48%	1.02 (0.60–1.75)	.9358
18–64, Cholecystitis	30,748	5,932	49	0.83%	29,458	341	1.16%	0.71 (0.53–0.96)	.0267	6,273	62	0.99%	0.83 (0.57–1.22)	.3455
18–64, Fractures Upper Limb	30,748	5,932	11	0.19%	29,458	84	0.29%	0.65 (0.35–1.22)	.1796	6,273	21	0.33%	0.55 (0.27–1.15)	.1121
≥65, Appendicitis	140,619	36,541	39	0.11%	165,386	230	0.14%	0.77 (0.54–1.09)	.1340	34,255	54	0.16%	0.68 (0.45–1.03)	.0672
≥65, Nephrolithiasis	140,619	36,541	44	0.12%	165,386	205	0.12%	0.97 (0.70–1.35)	.8625	34,255	45	0.13%	0.92 (0.60–1.39)	.6810
≥65, Cholecystitis	140,619	36,541	232	0.63%	165,386	1,117	0.68%	0.94 (0.81–1.09)	.398	34,255	236	0.69%	0.92 (0.77–1.11)	.3792
≥65, Fractures Upper Limb	140,619	36,541	156	0.43%	165,386	843	0.51%	0.74 (0.62–0.89)	.0590	34,255	188	0.55%	0.78 (0.62–0.97)	.0277

^aMarketScan CCAE data from 2010–2018; CMS Medicare data from 2014–2018.