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Schematic expression of how PAMPs and DAMPs enhance the body’s anti-tumor immunity. PAMPs and DAMPs bind to PRR receptors in the APC membrane or cytoplasm and enhance APC activation and uptake of tumor antigens, presenting them to T cells to activate them. On the one hand, activated T cells induced apoptosis of tumor cells through the Fas/FasL pathway. On the other hand, they can also assist B cell activation to produce specific antibodies to destroy the tumor.
