Table 2.

Adverse events^†

	Any grade			Grade 3, 4
	n	%		n	%
Hematological AEs
Leukocytopenia	40	83		21	44
Neutropenia	35	73		22	46
Anemia	32	67		6	13
Thrombocytopenia	21	44		4	8
Nonhematological AEs
Anorexia	20	42		2	4
Diarrhea	14	29		0	0
Constipation	16	33		0	0
Nausea	22	46		0	0
Fatigue	33	48		1	2
Alopecia	21	44		0	0
Fever	19	40		0	0
Injection site reaction	48	100		0	0
Peripheral sensory neuropathy	20	42		0	0
Pain	18	38		0	0
ALT elevation	17	35		1	2
AST elevation	16	33		1	2
Bilirubin elevation	11	23		0	0
ALP elevation	10	21		0	0
Hypoalbuminemia	15	31		0	0

^†Adverse Events (AEs) listed are those that occurred in more than 20% of patients. The US National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 was used to classify the grades. ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase.