Table 4.
Univariate analysis of the association of laboratory factors with PFS and OS
| Factor | Group | n | PFS |
OS |
|||
|---|---|---|---|---|---|---|---|
| Median survival | p value | Median survival | p-value | ||||
| WBC | ≧4380/mm3 | 24 | 8.4 (4.2–11.6) | 0.479 | 14.7 (7.6–23.1) | 0.621 | |
| <4380/ mm3 | 24 | 8.1 (3.7–13.4) | 15.1 (8–23.8) | ||||
| Hb | ≧11.4 g/dL | 24 | 8.4 (4.2–11.6) | 0.99 | 15.1 (8–18.9) | 0.808 | |
| <11.4 g/dL | 24 | 6.8 (3.7–12.6) | 13.1 (7.1–23.9) | ||||
| Plt | ≧199/ mm3 | 25 | 7.9 (4.2–9.3) | 0.42 | 15.1 (7.6–23.8) | 0.734 | |
| <199/ mm3 | 23 | 8.8 (3.7–12.6) | 17.4 (9.3–23.1) | ||||
| Alb | ≧3.95 g/dL | 24 | 8.1 (4.3–12.6) | 0.596 | 17.4 (9.3–23.1) | 0.447 | |
| <3.95 g/dL | 24 | 8.4 (3.5–12.6) | 14.7 (7.1–23.9) | ||||
| CRP | ≧0.195 mg/dL | 24 | 8.4 (4.4–12.6) | 0.899 | 18.5 (7.1–23.) | 0.857 | |
| <0.195 mg/dL | 24 | 7.9 (3.5–13.7) | 15.1 (8–23.1) | ||||
| CA19.9 | ≧499.8 U/ml | 24 | 8.4 (4.2–12.6) | 0.858 | 15.1 (7.7–18.9) | 0.291 | |
| <499.8 U/m | 24 | 7.9 (3.7–12.6) | 15.1 (7.9–23.8) | ||||
| CEA | ≧7.0 mg/ml | 19 | 4.7 (3.0–9.3) | 0.0444* | 8.0 (5.1–18.5) | 0.203 | |
| <7.0 mg/ml | 19 | 8.4 (4.9-NA) | 18.9 (9.3–23.8) | ||||
| NLR | ≧5 | 11 | 4.2 (3.3-NA) | 0.0206* | 8.0 (6.6–15.1) | 0.0164* | |
| <5 | 37 | 9.2 (6.8–12.6) | 17.4 (13.1–23.8) | ||||
| PNI | ≧40 | 40 | 9.2 (6.8–12.6) | 0.0174* | 17.4 (13.4–23.1) | 0.0109* | |
| <40 | 8 | 4.6 (1.9-NA) | 7.4 (3.4–13.1) | ||||
| mGPS | 0 | 36 | 9.2 (6.8–12.6) | 0.0169* | 17.4 (13.4–23.1) | 0.0251* | |
| 1.2 | 12 | 4.4 (3.0–8.8) | 7.4 (3.9–13.1) | ||||
| PLR | ≧150 | 32 | 6.8 (3.6–9.2) | 0.0228* | 13.1 (7.7–18.5) | 0.0604 | |
| <150 | 16 | 11.6 (4.4-NA) | 18.9 (14.7-NA) | ||||
| WT1 | Weak | 33 | 8.8 (4.3–11.6) | 0.62 | 14.7 (7.9–23.1) | 0.968 | |
| Moderate | 15 | 8.4 (3.5-NA) | 17.4 (4.8–23.8) | ||||
| MUC1 | Weak | 19 | 8.1 (3.7–12.6) | 0.746 | 18.5 (7.1–23.1) | 0.799 | |
| Moderate | 29 | 7.1 (4.2–13.4) | 14.7 (7.9-NA) | ||||
Two groups were divided by the median value. The cutoff values for the NLR, PNI mGPS and PLR are determined on the basis of previous studies.17,32–34 The classification of the intensity of staining in immunohistochemistry is determined on the basis of the report by Kanai et al.35 Weak represents faint and barely perceptible staining in PDAC cells under high magnification (x200). Moderate represents moderate complete staining under low magnification (x40). Parenthesis represents a 95% confidence interval. PFS, progression free survival; OS, overall survival; WBC, white blood cell; Hb, hemoglobin; Plt, platelet; Alb, albumin; CRP, C-reactive protein; CA19-9, carbohydrate antigen 19–9; CEA, carcinoembryonic antigen; NLR, neutrophil to lymphocyte ratio; PNI, prognostic nutritional index; mGPS, modified Glasgow prognostic score; PLR, platelet to lymphocyte ratio; WT1, Wilms’ tumor 1 staining; MUC1, Mucin 1 staining. * represents statistically significant.