TABLE 1.
Summary of input parameters used in the dexketoprofen PBPK model.
| Parameter (Unit) | Value | References/Comments |
|---|---|---|
| Dose (mg) | 25 | Barbanoj et al. (2001) |
| Caco-2 cell P app (×10−6 cm/s) | 81.60 | Laitinen et al. (2003) |
| Predicted P eff,man (cm/h) | 3.37 | Predicted by Simcyp® Simulator, version 18 |
| K dis (1/h) | 8.16 (pH 1.2) | Curve fit |
| 6.59 (pH 4.5) | Curve fit | |
| 8.29 (pH 6.8) | Curve fit | |
| K tgs (1/h) | 1.65 | Wilding et al. (2003) |
| K tgl (1/h) | 5.67 | Calculated a |
| K t (1/h) | 2.10 | Yu et al. (1996) |
| Vc (L) | 3.55 | Fitted by Phoenix WinNonlin (7.0) software |
| K 12 (1/h) | 1.14 | Fitted by Phoenix WinNonlin (7.0) software |
| K 21 (1/h) | 1.24 | Fitted by Phoenix WinNonlin (7.0) software |
| K 10 (1/h) | 1.68 | Fitted by Phoenix WinNonlin (7.0) software |
| A (mg/L) | 11.04 | Fitted by Phoenix WinNonlin (7.0) software |
| B (mg/L) | 3.20 | Fitted by Phoenix WinNonlin (7.0) software |
| Alpha (1/h) | 3.45 | Fitted by Phoenix WinNonlin (7.0) software |
| Beta (1/h) | 0.60 | Fitted by Phoenix WinNonlin (7.0) software |
a
Mean value of 10,000 times gastric emptying model simulation results.