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Results for Cmax in virtual BE trials simulated by the DEX PBPK model.
| Subjects number | Demonstrate BE | Non-BE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fail to demonstrate BE | Fail to demonstrate BIE | Demonstrate BIE | Total | |||||||
| 24 (%) | 48 (%) | 24 (%) | 48 (%) | 24 (%) | 48 (%) | 24 (%) | 48 (%) | 24 (%) | 48 (%) | |
| Fast | 60.0 | 89.0 | 37.0 | 10.8 | 3.0 | 0.2 | 0.0 | 0.0 | 40.0 | 11.0 |
| Median | 85.5 | 99.4 | 14.4 | 0.6 | 0.1 | 0.0 | 0.0 | 0.0 | 14.5 | 0.6 |
| Slow | 52.8 | 80.4 | 43.6 | 18.6 | 3.6 | 1.0 | 0.0 | 0.0 | 47.2 | 19.6 |
