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. 2022 Feb 25;49(4):54. doi: 10.3892/ijmm.2022.5110

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Myricetin-induced apoptosis occurs through the MAPK pathway in SK-BR-3 cells. (A) Western blot analysis of expression levels of cleaved PARP, Bax, and Bcl-2 in SK-BR-3 cells after myricetin (10, 20 µM) treatment. (B) Western blot analysis of SK-BR-3 cells treated with myricetin (10 and 20 µM for 24 h) to measure the levels of ERK, p-ERK, JNK, p-JNK, p38, and p-p38 proteins. The control group (0 µM) was treated with the same amount of DMSO, and β-actin was used as a loading control. Data are displayed as the mean ± SD (n=3). ^*P<0.05 vs. control group. PARP, polyadenosine diphosphate-ribose polymerase; Bax, Bcl-2 associated X; Bcl-2, B cell lymphoma 2; MAPK, mitogen-activated protein kinase; ERK, extracellular-regulated kinase; JNK, c-Jun N-terminal kinase; p38, p38 mitogen-activated protein kinases; DMSO, dimethyl sulfoxide.