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. 2022 Feb 18;49(4):53. doi: 10.3892/ijmm.2022.5109

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Copyright: © Feng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Wogonin treatment following TBI improved neurobehavioral function and reduced cerebral edema. (A) The neurological severity scores of rats in the sham operation group (sham), TBI model group (TBI) and wogonin administration group (Wog) were recorded on the 1, 3, 5, 7 and 14 days after the operation. (B) The brain water content of the three groups of rats on the 3rd day was tested. (C) In the Morris water maze test, the latency time of the three groups of rats looking for a hidden platform was recorded. (D) On the 7th day, the three groups of rats were tested in the quadrant time of the target quadrant of the removal platform. (E) The swimming speed of the three groups of rats was tested. Data are expressed as mean ± standard deviation (n=5/group; ^*P<0.05 vs. sham group; ^#P<0.05 vs. TBI group). TBI, traumatic brain injury.