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. 2022 Feb 18;49(4):53. doi: 10.3892/ijmm.2022.5109

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Copyright: © Feng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Wogonin increases the protein levels of Nrf2 and HO-1 following TBI in the hippocampus through the PI3K/Akt pathway. (A) Western blotting assays of Nrf2 and HO-1 were performed in the hippocampal CA1 region of the sham group, TBI group, TBI + Wog group, TBI + Wog + LY group and TBI + DMSO group at 24 h after the operation. The optical density of (B) Nrf2 and (C) HO-1 bands relative to β-actin was analyzed. (D) Representative immunofluorescence confocal images were used to evaluate the co-localization of Nrf2 (green) and NeuN (red). (E) The quantitative analysis of Nrf2-positive NeuN in the hippocampus. Scale bar, 50 µm. ^*P<0.05 vs. sham group; ^#P<0.05 vs. TBI group; ^$P<0.05 vs. TBI + Wog group; ^&P< vs. TBI + Wog + LY group. Nrf2, nuclear factor-erythroid factor 2-related factor 2; HO-1, heme oxygenase-1; TBI, traumatic brain injury.