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. 2022 Mar 9;20:89. doi: 10.1186/s12916-022-02281-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparison of adjusted total IgG and IgM against 15 P. vivax antigens following symptomatic infections. Fifteen antigens with IgM positivity at 1-week post-infection (> 2 SD above baseline median) were selected, and their IgM responses over a 9-month period were measured and compared to total IgG responses plotted on the same scale. Each line and colour represent an antibody class (either IgG or IgM) and its specific antibody kinetics following exposure. Data were adjusted by subtracting the median of pooled negative control panels (n = 274). Data are expressed as the median ± 95% CI