TABLE 4.
Relevant mechanosensitive molecules in CHP and SMG groups as compared to static controls within female and male donor cohorts. *q < 0.05, **q < 0.01, ***q < 0.001 represent statistical difference of the two groups in each fold change value.
| Gene | Description | Fold change: CHP/Static | Fold change: SMG/Static | ||||
|---|---|---|---|---|---|---|---|
| Female | Male | Combined | Female | Male | Combined | ||
| CAV1 | Caveolin 1 | 1.92* | 1.51 | 1.68** | 1.40 | 1.40 | 1.40* |
| CAV2 | Caveolin 2 | 1.42* | 1.28 | 1.34** | 1.07 | −1.15 | −1.04 |
| FOSB | FosB Proto-Oncogene, AP-1 Transcription Factor Subunit | 137.8* | 9.70 | 49.48** | 2.82 | 3.66 | 3.40 |
| PIEZO1 | Piezo Type Mechanosensitive Ion Channel Component 1 | 1.19 | 1.41 | 1.30 | -1.02 | 1.09 | 1.04 |
| RUNX2 | RUNX Family Transcription Factor 2 | 1.13 | −1.13 | 1.02 | −1.14 | 1.07 | −1.04 |
| TMEM63A | Transmembrane Protein 63A | −1.05 | −1.13 | −1.09 | 1.15 | 1.22 | 1.19 |
| TMEM63B | Transmembrane Protein 63B | 1.04 | 1.18 | 1.11 | 1.25 | 1.38 | 1.32 |
| TMEM63C | Transmembrane Protein 63C | 1.43 | 1.42 | 1.43 | −1.24 | −1.20 | −1.22 |
| TRPV1 | Transient Receptor Potential Cation Channel Subfamily V Member 1 | −1.62 | −1.21 | −1.37 | −1.16 | −1.03 | −1.08 |
| TRPV4 | Transient Receptor Potential Cation Channel Subfamily V Member 4 | 1.25 | 1.02 | 1.11 | −1.10 | −1.16 | −1.13 |