Table 1.
Results of meta-analysis of altered resting-state functional connectivity in α-Synucleinopathy compared with healthy control.
| Seeds network | Connected region (peak location) | BA | Voxels | SDM-Z | MNI coordinate | Located network |
|---|---|---|---|---|---|---|
| FPN | Hyperconnectivity | |||||
| R-MPFC | 10 | 303 | 4.386 | 4,50,0 | DMN | |
| R-SMA | 6 | 191 | 4.019 | 2,16,54 | SMN | |
| Hypoconnectivity | ||||||
| L-cerebellum IV / V | 19 | 3053 | -6.642 | -16,-56,-16 | CN | |
| R-IPG | 40 | 289 | -4.746 | 50,-48,44 | FPN | |
| R-cerebellum IV / V | 37 | 211 | -4.354 | 20,-50,-28 | CN | |
| R-anterior thalamic projections | NA | 213 | -4.165 | 12,12,6 | subcortical network | |
| L-striatum | NA | 132 | -3.997 | -14,20,-2 | subcortical network | |
| DMN | Hypoconnectivity | |||||
| R-STG | NA | 1131 | -5.307 | 48,8,-12 | DMN | |
| L-rolandic operculum | 48 | 966 | -4.705 | -48,6,2 | VAN | |
| L-MPFC | 32 | 94 | -3.975 | 2,34,28 | DMN | |
| R-insula | 48 | 81 | -3.831 | 36,18,2 | VAN | |
| CN | Hypoconnectivity | |||||
| R-striatum | 48 | 568 | -6.241 | 32,-6,8 | subcortical network | |
| R-insula/operculum | 48 | 459 | -6.22 | 36,-2,12 | VAN | |
| R-STG/MTG/ITG | 20/21/22 | 500 | -6.978 | 48,-10,-12 | DMN | |
| R-STG/angular/IPG | 42/39/40 | 1248 | -6.9 | 52,-42,18 | DMN/FPN | |
| R-Precuneus/PCC | 23 | 676 | -6.044 | 4,-46,38 | DMN | |
| ACC/OFC | 10/11 | 676 | -5.675 | -4,42,-4 | DMN | |
| R-DLPFC | 9 | 118 | -4.676 | 22,-10,-26 | FPN | |
|
Subcortical Network |
Hyperconnectivity | |||||
| L-postCG | 4 | 85 | 4.999 | -26,-30,64 | SMN | |
| Hypoconnectivity | ||||||
| R-Precuneus | 23 | 364 | -4.688 | 2,-34,32 | DMN | |
| L-insula | 47 | 166 | -3.873 | -26,20,-6 | VAN | |
| L-STG | 42 | 122 | -3.967 | -58,-46,20 | DMN | |
| SMN | Hypoconnectivity | |||||
| R-lenticular nucleus, putamen | 48 | 240 | -3.961 | 30,-4,0 | subcortical network | |
| L-lenticular nucleus, putamen | 106 | -3.738 | -28,0,0 | subcortical network | ||
| VAN | Hypoconnectivity | |||||
| R-PHG | 30 | 229 | -4.261 | 18,-20,-20 | LN | |
| L-insula | 48 | 157 | -3.79 | -36,-16,10 | VAN | |
| L-IFG, triangular part | 45 | 84 | -3.319 | -48,16,0 | VAN | |
| R-ACC | 24 | 54 | -3.145 | 6,12,38 | VAN | |
| LN | Hyperconnectivity | |||||
| Middle cerebellar peduncles | 212 | 4.314 | 12,-28,-30 | CN | ||
| Hypoconnectivity | ||||||
| L-sgACC | 25 | 54 | -3.292 | -2,24,-4 | VAN | |
| R-rolandic operculum | 48 | 50 | -3.214 | 46,-12,10 | VAN |
Abbreviations: BA, Brodmann area; SDM-Z, seed-based d mapping-z value; MNI, Montreal Neurological Institute; FPN, frontoparietal network; R-, the right; L-, the left; DMN, default mode network; CN, cerebellar network; SMN, somatomotor network; VAN, ventral attention network; LN, limbic network, MPFC, medial prefrontal cortex, SMA, supplementary motor area, IPG, inferior parietal gyrus; STG, superior temporal gyrus; MTG, middle temporal gyrus; ITG, inferior temporal gyrus; DLPFC, dorsolateral prefrontal cortex; sgACC, subgenual anterior cingulate cortex; OFC, orbital prefrontal cortex; postCG, posterior central gyrus; PCC, posterior cingulate cortex; PHG, parahippocampal gyrus.