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. 2022 Mar 1;8(3):e09033. doi: 10.1016/j.heliyon.2022.e09033

Figure 2.

Figure 2

The identification of hub ARGs in CRC 5-FU resistance. a: The IC50 5-FU response data of 44 CRC cell lines in GDSC database. The IC50 value was significant higher in SW1116, LS-123, HT55, HT-115, SW1417 cells but lower in SNU-407, RKO, HCT-116, LS-411N, LS-513 cells (p < 0.05). b: The genomic information of CRC cells with different 5-FU IC50 response. By verification of 34 ARGs expression in CCLE, high expression of ATG9B, HSPB8 and PINK1 were determined to be the hub ARGs correlated to 5-FU resistance. c: The association between hub ARGs expression and CRC overall survival (OS) and disease-free survival (DFS). CRC patients with high HSPB8 expression were found to have a significant shorter OS and DFS time than patients with low HSPB8 expression (p < 0.05).