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. 2022 Feb 22;9:780166. doi: 10.3389/fped.2021.780166

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Copyright © 2022 Serapiglia, Stephens, Joshi, Aydin, Oria, Marotta, Peiro and Varisco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fetal endoscopic tracheal occlusion (FETO) increases the number and distalization of lung basal cells. (A) The percentage of lung basal cells as defined by the co-expression of EpCam and NGFR increased from ~1.5 to ~2.5% at E18.5 following tracheal occlusion (TO) at E16.5. (B) The increased percentage of basal cells in TO (n = 6) compared to control (n = 7) was consistent and statistically significant. (C) The whole-lung protein content of the basal cell marker keratin-14 was also increased (n = 5 per group). (D) Immunohistochemistry of control lung for NGFR showed restriction of basal cells to the basement membrane of large conducting airways. (E) FETO lungs had increased cellularity and had extension of basal cells beyond the central conducting airways into the more distal conducting airways. (D′), Magnified Image of D; (E′), Magnified Image of E.