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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Addiction. 2021 Oct 14;117(4):877–889. doi: 10.1111/add.15674

Table 3.

Moderator effects for alcohol-targeted interventions, by outcome domain.

Outcome domain
Alcohol use Consequences
Categorical moderators
Comparison group type
 Other types 0.12 [0.06, 0.19] 62, 501 0.03 [−0.13, 0.20]20, 102
 Treatment as usual 0.10 [0.03, 0.17] 62, 501 0.06 [0.00, 0.13]20, 102
Implementation monitoring
 Yes 0.10 [0.05, 0.15] 62. 501 0.06 [−0.01, 0.13]20, 102
 Not reported 0.14 [0.05, 0.23] 62, 501
Implementation problems
 Yes 0.15 [−0.04, 0.35]62, 501
 Possible 0.05 [−0.02, 0.13]62, 501
 Not reported 0.11 [0.06, 0.16] 62, 501
Intention-to-treat analysis
 Yes 0.10 [0.05, 0.15] 61, 497 0.09 [0.02, 0.16]20, 102
 Possible 0.11 [−0.02, 0.24]61, 497
 No 0.14 [0.03, 0.26] 61, 497
CONSORT diagram reported
 Yes 0.08 [0.04, 0.12] 62, 501 0.03 [−0.04, 0.11]20, 102
 No 0.24 [0.07, 0.41] 62, 501
Overall risk of bias
 High 0.02 [−0.07, 0.11]62, 501
 Unclear 0.14 [0.08, 0.19] 62, 501 0.07 [0.01, 0.14]20, 102
Setting
 Emergency department 0.05 [0.00, 0.10]62, 501 0.00 [−0.08, 0.08]20, 102
 General medical setting 0.17 [0.10, 0.24] 62, 501 0.11 [0.02, 0.20]20, 102
Modality
 In-person 0.14 [0.08, 0.20] 61, 497
 Computer/tablet/smartphone 0.10 [0.01, 0.18]61, 497
 Telephone 0.01 [−0.07, 0.10]61, 497
Booster delivered
 Yes 0.16 [0.07, 0.25] 62, 501
 No 0.10 [0.04, 0.15] 62, 501 0.03 [−0.04, 0.11]20, 102
Age group
 Adolescent/young adult 0.11 [0.04, 0.18] 62, 501
 Mixed or adult only 0.12 [0.06, 0.17] 62, 501 0.02 [−0.06, 0.10]20, 102
Continuous moderators
Overall attrition −0.28 [−0.78, 0.22]58, 493 0.15 [−0.33, 0.64]20, 102
Differential attrition 0.47 [−0.82, 1.77]52, 371 0.19 [−4.60, 4.99]16, 69
Efficacy-to-effectiveness scale score −0.01 [−0.03, 0.01]62, 501 −0.02 [−0.05, 0.02]20, 102
Duration 0.00 [−0.003. 0.004]54, 443 0.00 [−0.01, 0.003]16, 90
Proportion female −0.21 [−0.52, 0.09]58, 487 0.24 [−0.05, 0.52]19, 100
Proportion white 0.02 [−0.23, 0.28]33, 280

Notes. Predicted mean effect sizes and 95% CIs presented for categorical moderators. Unstandardized coefficients and 95% CIs presented for continuous moderators. Results in boldface are significantly different from zero after Benjamini-Hochberg adjustment for multiple comparisons. k (number of studies), n (number of effect sizes). — not estimable due to limited degrees of freedom.