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. 2022 Feb 23;13:818569. doi: 10.3389/fimmu.2022.818569

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Copyright © 2022 Van Loon, Lamarthée, Barba, Claes, Coemans, de Loor, Emonds, Koshy, Kuypers, Proost, Senev, Sprangers, Tinel, Thaunat, Van Craenenbroeck, Schols and Naesens

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine profiles in supernatants of NK cells and/or monocytes cocultured with HLA class I antibody-activated glomerular endothelial cells or isotype antibodies. (A) NK cell experiment using NK cells from 7 human donors, cocultured with human antibody serum (anti-HLA-A2-containing serum or control pooled serum that was negative for anti-HLA A2) and ciGENC (immortalized glomerular endothelial cells), harvested after 4 h. (B) NK cell and monocyte experiment using NK cells and CD16+ monocytes from 5 human donors, cocultured with murine antibody (anti-HLA-A, -B, -C, or control isotype) and GENC (primary glomerular endothelial cells, Cell Systems, USA); harvesting of supernatants was done after 24 h of coculture. Violin plots of the cytokine concentrations (pg/mL) of the significantly differently expressed cytokines in both conditions, as assessed by a paired parametric T-test of the log10 transformed concentrations.