Table 1.
Sample characteristics of first and all biopsies.
| First biopsies (N = 192) | All biopsies (N = 293) | |
|---|---|---|
| Mean ± std | ||
| Or median (IQR) | ||
| Or no (%) | ||
| Clinical parameters | ||
| Serum C reactive protein, mg/L | 9.0 (1.8–24.7) | 5.3 (1.4–18.3) |
| eGFR, MDRD, mL/min | 19.6 ± 13.1 | 19.8 ± 12.2 |
| Proteinuria, g/g creatinine | 0.3 (0.2–1.1) | 0.3 (0.2–0.8) |
| Time after transplantation (days) | 11 (7–24) | 18 (9–51) |
| HLA-DSA at time of biopsy | 17 (8.9%) | 29 (9.9%) |
| HLA-DSA at time of transplant | 17 (8.9%) | 34 (11.6%) |
| De novo HLA-DSA | 2 (1.0%) | 6 (2.1%) |
| Histological diagnosis | ||
| Any rejection | 72 (37.5%) | 106 (36.2%) |
| - ABMR (pure) | 5 (2.6%) | 7 (2.4%) |
| - TCMR (pure) | 35 (18.2%) | 54 (18.4%) |
| - Borderline changes (pure) | 22 (11.5%) | 26 (8.9%) |
| - Mixed rejection | 10 (5.2%) | 19 (6.5%) |
| Histological lesion scores | ||
| Glomerulitis > 0 | 33 (17.2%) | 53 (18.1%) |
| Peritubular capillaritis > 0 a | 19 (9.9%) | 37 (12.6%) |
| Tubulitis >0 | 128 (66.7%) | 200 (68.3%) |
| Interstitial inflammation >0 | 51 (26.6%) | 73 (24.9%) |
| Intimal arteritis >0 | 38 (19.8%) | 62 (21.2%) |
| C4d ptc >1 a | 17 (8.9%) | 24 (8.2%) |
| Trombi (yes) | 10 (5.2%) | 14 (4.8%) |
| ABMRh (yes) | 23 (12.0%) | 41 (14.0%) |
| Arteriolar hyalinosis >1 | 25 (13.0%) | 44 (15.0%) |
| Vascular intimal thickening >1 | 40 (20.8%) | 70 (23.9%) |
| Interstitial fibrosis >1 | 7 (3.7%) | 25 (8.5%) |
| Tubular atrophy >1 | 4 (2.1%) | 11 (3.8%) |
| Transplant glomerulopathy >0 | 0 | 3 (1.0%) |
| Mesangial matrix expansion>0 | 10 (5.2%) | 19 (6.5%) |
aMissing data for peritubular capillaritis (N = 5 in first biopsies, and N = 6 in all biopsies), C4d deposition in ptc (N = 6 in first biopsies, N = 9 in all biopsies).