TABLE 2.
Incidence of depression and anxiety in diabetes patients with/without GLP1-RA use.
| Outcome variables | Non-GLP1-RA vs. GLP1-RA user | |
|---|---|---|
| Non-GLP1-RA user | GLP1-RA user | |
| Any depression or anxiety | ||
| Follow-up years | 1.97 ± 1.53 | 2.62 ± 1.51 |
| Event | 857 | 157 |
| Person-year | 91546 | 23090 |
| Incidence Rate | 9.36 | 6.80 |
| Crude HR (95% CI) | ref. | 0.72 (0.60, 0.85)*** |
| Model 1 | ref. | 0.73 (0.61, 0.86)*** |
| Model 2 | ref. | 0.73 (0.62, 0.87)*** |
| Model 3 | ref. | 0.80 (0.67, 0.95)** |
| Anxiety | ||
| Follow-up years | 1.93 ± 1.52 | 2.39 ± 1.48 |
| Event | 656 | 116 |
| Person-year | 91838 | 23158 |
| Incidence Rate | 7.14 | 5.01 |
| Crude HR (95% CI) | ref. | 0.70 (0.57, 0.85)*** |
| Model 1 | ref. | 0.70 (0.58, 0.86)*** |
| Model 2 | ref. | 0.71 (0.58, 0.86)*** |
| Model 3 | ref. | 0.78 (0.64, 0.95)* |
| Depression | ||
| Follow-up years | 2.08 ± 1.57 | 2.92 ± 1.60 |
| Event | 308 | 68 |
| Person-year | 92594.49 | 23304.4 |
| Incidence Rate | 3.32 | 2.91 |
| Crude HR (95% CI) | ref. | 0.85 (0.66, 1.11) |
| Model 1 | ref. | 0.85 (0.66, 1.11) |
| Model 2 | ref. | 0.87 (0.67, 1.14) |
| Model 3 | ref. | 0.94 (0.72, 1.23) |
*p < 0.05, **p < 0.01, ***p < 0.001.
Incidence rate, per 1,000 person-years; HR, hazard ratio; CI, confidence interval.
Demographic factors include age, gender, urbanization level and enrollee category.
1:4 propensity score matching.
Model 1: Adjust for demographic factors.
Model 2: Adjust for model 1 + comorbidity.
Model 3: Adjust for model 2 + medication.