TABLE 7.
Cox proportional hazard model estimated GLP1-RA hazard ratio of depression among different GLP1-RA types.
| Variables | Depression | cHR | (95% CI) | aHR # | (95% CI) | ||
|---|---|---|---|---|---|---|---|
| n | PY | IR | |||||
| Non-use GLP1-RA | 329 | 102,822 | 3.20 | 1.00 | (Reference) | 1.00 | (Reference) |
| Liraglutide | 47 | 13,077 | 3.59 | 1 | (0.73, 1.36) | 1.13 | (0.82, 1.54) |
| Non-use GLP1-RA | 356 | 111,188 | 3.20 | 1.00 | (Reference) | 1.00 | (Reference) |
| Exenatide | 20 | 4,711 | 4.25 | 1.13 | (0.71, 1.78) | 1.43 | (0.90, 2.28) |
| Non-use GLP1-RA | 363 | 106,247 | 3.42 | 1.00 | (Reference) | 1.00 | (Reference) |
| Dulaglutide | 13 | 9,652 | 1.35 | 0.44 | (0.25, 0.78)** | 0.45 | (0.26, 0.79)** |
PY: person-years; IR: incidence rate per 1,000 person-years; cHR: crude hazard ratio; aHR: adjusted hazard ratio.
1:4 propensity score matching.
#
: adjusted by sex, age, urbanization level, enrollee category, comorbidities and medication; *p < 0.05, **p < 0.01, ***p < 0.001.