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. 2022 Mar 8;13(3):217. doi: 10.1038/s41419-021-04446-5

Fig. 4. c-Myc silencing inactivates KCNQ1OT1 to dampen GC cell viability, migration, and invasion.

Fig. 4

A The expression of KCNQ1OT1 in GC cells overexpressing c-Myc determined by RT-qPCR. B RT-qPCR was used to detect the expression of KCNQ1OT1 in GC cells knocking down c-Myc. GC cells were transfected with si-NC, si-c-Myc, or si-c-Myc + oe-KCNQ1OT1. C RT-qPCR was used to detect the expression of c-Myc and KCNQ1OT1 in cells. D Cell viability determined by CCK-8. E Cell apoptosis rate measured by flow cytometry. F Cell migration detected by Transwell assay. G The invasion of GC cells assessed by Transwell assay. * represents the comparison between the two groups. *p < 0.05; **p < 0.01; ***p < 0.001. The cell experiment was repeated 3 times.