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. 2022 Mar 8;12:3775. doi: 10.1038/s41598-022-06632-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic representation of the workflow of the SARS-CoV-2 swab-to-qcLAMP detection, i.e. without RNA purification. (b) Scattered plot of the Ct values of PCR-confirmed positive samples by using the HNB colorimetric dye inside the LAMP-mix. (c) Table presenting overall diagnostic sensitivity and specificity of the qcLAMP for fresh and frozen samples; the red and blue colors are used to guide the eye and depict fresh and frozen samples, respectively. (d) when considering various Ct cut off values. For Ct < 30 sensitivity becomes 98% (95% CI: 95–101) and negative likelihood ratio 0.016 (95% CI: 0.002–0.109); for Ct < 25, sensitivity is calculated to be 100%.