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. 2022 Mar 8;5:211. doi: 10.1038/s42003-022-03149-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — (a) C-to-T conversion by CjCas9-AID (gray) and enCjCas9-AID (orange) at endogenous target sites in HEK293Ta cells (n = 3). (b) Summary of the base-editing efficiencies of CjCas9-AID (gray) and enCjCas9-AID (orange) in (a). Bars indicate medians. (c) C-to-T conversion by CjCas9-AID (gray), enCjCas9-AID (orange), and SpCas9-AID (blue) at endogenous target sites in HEK293Ta cells (n = 3).