Table 5.

Enriched pathways and GO terms in pan-cancer.

REACTOMEa	KEGGb	GO termsc
Immune System Metabolism Signal Transduction Innate Immune System Hemostasis Transport of small molecules Developmental Biology Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding GPCR downstream signalling G alpha (i) signalling events Neuronal System	Neuroactive Ligand Receptor Interaction Metabolism of Xenobiotics by Cytochrome P450 Steroid Hormone Biosynthesis Retinol Metabolism Drug Metabolism Cytochrome P450 Cytokine-Cytokine Receptor Interaction Systemic Lupus Erythematosus	Receptor ligand activity Receptor regulator activity Ion gated channel activity Gated channel activity Cation channel activity Substrate-specific channel activity Passive transmembrane transporter activity Extracellular matrix Ion channel activity Nucleosome DNA packaging complex Nuclear nucleosome Protein-DNA complex Hormone activity

The pathways that appeared in more than four cancer types are in bold.

^aREACTOME pathways, ^bKEGG pathways and ^cGO terms that were found to be enriched in at least two cancer types.