Table 2.

External validation of PRS models in European populations using data from UK Biobank and CIMBA.

Model (data set)	SNPs	UK Biobank			CIMBA BRCA1 carriersa			CIMBA BRCA2 carriersa
		AUC	OR	95% CI	AUC	HR	95% CI	AUC	HR	95% CI
(a) PRS models based on OCAC data
Lasso (OCAC)	1403	0.587	1.37	1.27–1.48	0.573	1.27	1.21–1.34	0.627	1.48	1.33–1.63
Elastic net (OCAC)	10,797	0.588	1.36	1.26–1.47	0.583	1.32	1.26–1.39	0.617	1.47	1.33–1.63
Stepwise (OCAC)	22	0.588	1.35	1.26–1.46	0.563	1.21	1.16–1.26	0.605	1.39	1.26–1.54
Select and shrink (OCAC)	27,240	0.588	1.38	1.28–1.48	0.592	1.36	1.29–1.43	0.624	1.49	1.35–1.64
(b) PRS models based on meta-analysis of OCAC and CIMBA data
Stepwise (OCAC-CIMBA)b	36	0.595	1.39	1.29–1.50	NA	NA	NA	NA	NA	NA
Select and shrink (OCAC-CIMBA)	18,007	0.596	1.42	1.32–1.54	NA	NA	NA	NA	NA	NA

AUC area under the receiver operating characteristic curve, OR odds ratio, HR hazards ratio.

^aEstimates are from unadjusted models.

^bResults in CIMBA are overfitted as the CIMBA data was used for model development.