Table 3.
Association between polygenic risk scores and non-mucinous EOC by PRS percentiles and ancestry.
| UK Biobank | East Asian | African | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Percentile | Controls (n) | Cases (n) | OR (95% CI) | Controls (n) | Cases (n) | OR (95% CI) | Controls (n) | Cases (n) | OR (95% CI) | |
| (a) Lasso | ||||||||||
| 0–5 | 9880 | 12 | 0.42 (0.22–0.72) | 278 | 106 | 0.65 (0.51–0.83) | 35 | 19 | 0.89 (0.47–1.65) | |
| 5–10 | 9870 | 24 | 0.83 (0.52–1.27) | 271 | 112 | 0.71 (0.55–0.90) | 41 | 13 | 0.52 (0.25–1.01) | |
| 10–20 | 19,733 | 53 | 0.92 (0.66–1.27) | 487 | 280 | 0.98 (0.82–1.18) | 81 | 26 | 0.53 (0.31–0.88) | |
| 20–40 | 39,468 | 104 | 0.90 (0.69–1.18) | 993 | 541 | 0.93 (0.80–1.08) | 154 | 60 | 0.64 (0.42–0.99) | |
| 40–60 | 39,457 | 115 | 1 | 967 | 566 | 1 | 133 | 81 | 1 | |
| 60–80 | 39,425 | 147 | 1.28 (1.00–1.64) | 941 | 593 | 1.08 (0.93–1.25) | 136 | 78 | 0.94 (0.64–1.39) | |
| 80–90 | 19,699 | 87 | 1.52 (1.14–2.00) | 466 | 301 | 1.10 (0.92–1.32) | 63 | 44 | 1.15 (0.71–1.84) | |
| 90–95 | 9842 | 51 | 1.78 (1.27–2.46) | 214 | 169 | 1.35 (1.07–1.69) | 34 | 20 | 0.97 (0.51–1.78) | |
| 95–100 | 9830 | 64 | 2.23 (1.64–3.02) | 211 | 173 | 1.40 (1.12–1.76) | 27 | 27 | 1.64 (0.90–3.00) | |
| (b) Elastic net | ||||||||||
| 0–5 | 9876 | 17 | 0.67 (0.39–1.09) | 277 | 107 | 0.72 (0.56–0.92) | 35 | 19 | 0.90 (0.47–1.64) | |
| 5–10 | 9876 | 17 | 0.67 (0.39–1.09) | 271 | 112 | 0.78 (0.61–0.99) | 41 | 13 | 0.52 (0.25–1.01) | |
| 10–20 | 19,740 | 45 | 0.89 (0.62–1.26) | 497 | 270 | 1.02 (0.85–1.22) | 81 | 26 | 0.53 (0.31–0.88) | |
| 20–40 | 39,453 | 120 | 1.19 (0.91–1.55) | 967 | 567 | 1.10 (0.95–1.28) | 154 | 60 | 0.64 (0.42–0.96) | |
| 40–60 | 39,471 | 101 | 1 | 1000 | 533 | 1 | 133 | 81 | 1 | |
| 60–80 | 39,413 | 159 | 1.58 (1.23–2.03) | 926 | 608 | 1.23 (1.06–1.43) | 136 | 78 | 0.94 (0.64–1.39) | |
| 80–90 | 19,695 | 91 | 1.80 (1.36–2.40) | 457 | 310 | 1.27 (1.06–1.52) | 63 | 44 | 1.15 (0.71–1.84) | |
| 90–95 | 9841 | 52 | 2.07 (1.47–2.87) | 226 | 157 | 1.30 (1.04–1.64) | 34 | 20 | 0.97 (0.51–1.78) | |
| 95–100 | 9839 | 55 | 2.18 (1.56–3.02) | 207 | 177 | 1.60 (1.28–2.01) | 27 | 27 | 1.64 (0.90–3.00) | |
| (c) Stepwise | ||||||||||
| 0–5 | 9880 | 13 | 0.39 (0.21–0.67) | 254 | 130 | 0.90 (0.71–1.14) | 40 | 14 | 0.75 (0.37–1.44) | |
| 5–10 | 9874 | 19 | 0.57 (0.34–0.91) | 268 | 115 | 0.76 (0.59–0.96) | 43 | 11 | 0.55 (0.26–1.10) | |
| 10–20 | 19,742 | 44 | 0.67 (0.47–0.93) | 494 | 273 | 0.98 (0.81–1.17) | 80 | 27 | 0.72 (0.42–1.21) | |
| 20–40 | 39,470 | 102 | 0.77 (0.60–1.00) | 970 | 564 | 1.03 (0.89–1.19) | 142 | 72 | 1.09 (0.73–1.63) | |
| 40–60 | 39,440 | 132 | 1 | 979 | 564 | 1 | 146 | 68 | 1 | |
| 60–80 | 39,414 | 158 | 1.20 (0.95–1.51) | 951 | 583 | 1.08 (0.94–1.25) | 130 | 84 | 1.39 (0.93–2.07) | |
| 80–90 | 19,697 | 88 | 1.33 (1.02–1.75) | 456 | 311 | 1.21 (1.01–1.44) | 61 | 46 | 1.62 (1.00–2.61) | |
| 90–95 | 9853 | 41 | 1.24 (0.86–1.75) | 236 | 147 | 1.10 (0.87–1.38) | 35 | 19 | 1.17 (0.61–2.17) | |
| 95–100 | 9834 | 60 | 1.82 (1.33–2.46) | 220 | 164 | 1.32 (1.04–1.65) | 27 | 27 | 2.15 (1.17–3.95) | |
| (d) Select and shrink | ||||||||||
| 0–5 | 9957 | 16 | 0.54 (0.31–0.89) | 279 | 105 | 0.63 (0.49–0.81) | 38 | 16 | 0.71 (0.36–1.33) | |
| 5–10 | 9888 | 15 | 0.51 (0.29–0.85) | 254 | 129 | 0.85 (0.67–1.08) | 41 | 13 | 0.53 (0.26–1.03) | |
| 10–20 | 19,812 | 51 | 0.87 (0.62–1.20) | 489 | 278 | 0.96 (0.80–1.14) | 81 | 26 | 0.54 (0.32–0.90) | |
| 20–40 | 39,435 | 113 | 0.97 (0.75–1.25) | 1013 | 521 | 0.86 (0.75–1.00) | 156 | 58 | 0.62 (0.41–0.94) | |
| 40–60 | 39,512 | 117 | 1 | 961 | 572 | 1 | 134 | 80 | 1 | |
| 60–80 | 39,316 | 158 | 1.36 (1.07–1.73) | 950 | 584 | 1.03 (0.89–1.20) | 137 | 77 | 0.94 (0.63–1.40) | |
| 80–90 | 19,718 | 77 | 1.32 (0.98–1.76) | 434 | 333 | 1.29 (1.08–1.54) | 61 | 46 | 1.26 (0.79–2.02) | |
| 90–95 | 9791 | 45 | 1.55 (1.09–2.17) | 233 | 150 | 1.08 (0.86–1.36) | 30 | 24 | 1.34 (0.73–2.45) | |
| 95–100 | 9775 | 65 | 2.25 (1.65–3.03) | 215 | 169 | 1.32 (1.05–1.66) | 26 | 28 | 1.80 (0.99–3.31) | |
OR odds ratio, CI confidence interval.