Table 4.
External validation of PRS models in East Asian and African Populations.
Model | East Asian ancestries | African ancestries | ||||
---|---|---|---|---|---|---|
AUC | OR | 95% CI | AUC | OR | 95% CI | |
Lasso | 0.541 | 1.16 | (1.11–1.22) | 0.576 | 1.28 | (1.13–1.45) |
Elastic net | 0.543 | 1.17 | (1.12–1.23) | 0.574 | 1.29 | (1.14–1.47) |
Stepwise (OCAC) | 0.528 | 1.11 | (1.06–1.16) | 0.581 | 1.34 | (1.18–1.52) |
Select and shrink (OCAC) | 0.538 | 1.14 | (1.08–1.19) | 0.593 | 1.38 | (1.21–1.58) |
Stepwise (OCAC-CIMBA) | 0.542 | 1.17 | (1.11–1.23) | 0.594 | 1.37 | (1.20–1.56) |
Select and shrink (OCAC-CIMBA) | 0.537 | 1.14 | (1.08–1.19) | 0.596 | 1.41 | (1.23–1.61) |