Table 2.

The expression, function, and DNA methylation status of ncRNAs in HCC.

Detectable location	Methylation status	LncRNA/miRNA	Role	Expression	Targets	Function	References
HCC cells and tissues	Promoter gene CpG hypermethylation	miR-1	Tumor suppressor	Downregulated	FoxP1, MET, HDAC4	Inhibits cell cycle progression and promotes apoptosis	(36)
Tissues	Promoter gene CpG hypomethylation	miR-191	Tumor promoter	Upregulated	/	EMT	(37)
Tissues	Hypomethylation	miR-519d	Tumor promoter	Upregulated	CDKN1A/p21	Promotes cell proliferation, invasion and impairs apoptosis	(38)
Tissues	CpG island hypermethylation	miR-335	Tumor suppressor	Downregulated	/	/	(39)
Serum and tissues	Hypermethylation of the promoter	miR-132	Tumor suppressor	Downregulated	Akt pathway	/	(40)
Tissues	Hypomethylated	miR-429	Tumor promoter	Upregulated	RBBP4	/	(41)
Cell lines	Hypermethylation of CpG island	miR-148a	Tumor suppressor	Downregulated	DNMT1	Inhibits HCC cell proliferation and cell cycle progression	(42)
Tissues and cell lines	Hypermethylation of CpG island	miR-941	Tumor suppressor	Downregulated	KDM6B	Suppresses cell proliferation, migration, and invasion	(43)
Tissues	Hypomethylatedstatus	miR-429	Tumor promoter	Upregulated	PTEN	Enhances HCC migration and invasion, and EMT	(44)
Tissues	Hypermethylation of CpG island	miR-615-5p	Tumor suppressor	Downregulated	RAB24	Inhibits cell motility and metastasis	(45)
Tissues and cell lines	Hypermethylation	miR-142	Tumor suppressor	Downregulated	TGF-β	Suppresses cell vitality, proliferation, EMT and angiogenesis	(46)
/	Hypermethylated	miR-148a	Tumor suppressor	/	NF-κB	/	(47)
Serum and tissues	Promoter gene CpG hypermethylation	lnc SRHC	Downregulated	Downregulated	/	Inhibits cancer proliferation	(48)