Table 4.
The abnormally expressed miRNAs involved in functional regulation of immune cells.
| miRNA | Expression | Detectable location | Target gene and pathway | Immune target | References |
|---|---|---|---|---|---|
| miR-570 | Downregulated | Cell lines | / | CD3+CD4+T cells and CD3+CD8+IFN-γ+ T cells | (96) |
| miR-132 | Upregulated | T helper 17 cells | SNIP1 | Th17 cell differentiation and improves the function of Th17 | (97) |
| miR-34a | Downregulated | Cells and tissues | CCL22 signaling | Induces Treg cell recruitment | (98) |
| miR-146a | / | / | STAT3 | NK cell dysfunction | (99) |
| miR-889 | Upregulated | Tissues | MICB | NK cell-mediated cytotoxicity | (100) |
| miR-615-5p | Upregulated | NK cells | IGF-1R (repression) | NK cells cytotoxicity | (101) |
| miR-223-3p | / | / | / | secretion of IL-1β and IL-18 | (88) |
| miR-370 | Downregulated | Cells and tissues | ISG15 | Influences IFN-α sensitivity | (91) |
| miR-506 | Downregulated | NK cells | STAT3 | NK cell cytotoxicity | (102) |
| miR-26b-5p | Downregulated | Cells and tissues | PIM-2 | Promotes cytokine secretion in CD4+ and CD8+ cells | (103) |
| miR-561-5p | Upregulated | Tissues and cell lines | CX3CL1 | CX3CR1+ NK cells infiltration | (104) |
| miR-144/miR-451a | Downregulated | Cell lines and tissues | HGF | Macrophage M1 polarization and antitumor activity | (24) |
| miR-124 | Downregulated | Liver fibrosis Tissues | IQGAP1 through the NF-κB pathway | LX-2 cells, TNF-α, IL-1β and IL-6 | (89) |
| miR-15a/16-1 | Downregulated | Tissues | NF-κB1 | Disrupts the communication between Kupffer cells and Tregs | (105) |
| miR-152 | Downregulated | / | / | NK and T cells | (106) |