Table 2.

Comparison between polygenic score AUC/R² observed in UKB and estimated using lassosum.

Binary
Phenotype	Observed AUC	Estimated AUC	Difference
Depression	0.559	0.555	−0.004
T2D	0.642	0.651	0.010
CAD	0.597	0.624	0.027
IBD	0.677	0.792	0.115
MultiScler	0.657	0.785	0.128
RheuArth	0.632	0.500	−0.132
Breast_Cancer	0.658	0.698	0.040
Prostate_Cancer	0.691	0.721	0.030
Continuous
Phenotype	Observed R2	Estimated R2	Difference
Intelligence	0.008	0.023	0.015
BMI	0.081	0.074	−0.007
Height	0.110	0.156	0.046