Table 4.
Results from the Sensitivity Analysis Using Inverse Probability–Weighted Modeling to Report Adjusted Risks of Adverse Events Among Patients Hospitalized and Discharged after ED Evaluation for Chest Pain. Risk Reduction Reports the Difference between Hospitalized (Treated) and Discharged (Control) Patients for Comparisons among 30-Day Patient Outcomes
| Outcome | Adjusted risk | Risk reduction (RR) | Number needed to harm (NNH) | |
|---|---|---|---|---|
| Not hospitalized (control) (N= 62,876) Mean (Std error) |
Hospitalized (treated) (N= 16,164) Mean (Std error) |
Hospitalized adjusted risk-control adjusted risk Mean# (95% CI) |
1/absolute risk increase | |
| Death/AMI* |
0.003 (<0.001) |
0.007 (0.001) |
0.004 (0.003 to 0.005) |
1/0·004 = 250 |
| Death* |
0.001 (<0.001) |
0.003 (<0.001) |
0.001 (<0.001 to 0.002) |
1/0·001 = 1000 |
| Acute MI* |
0.002 (<0.001) |
0.004 (0.001) |
0.003 (0.001 to 0.004) |
1/0·003 = 333 |
| Coronary revascularization* |
0.002 (<0.001) |
0.004 (0.001) |
0.002 (0.001 to 0.003) |
1/0·002 = 500 |
| MACE* |
0.003 (<0.001) |
0.007 (0.001) |
0.004 (0.003 to 0.006) |
1/0·004 = 250 |
#Bold font indicates statistically significant differences
*Doubly robust inverse probability weighting model models with regression adjustment for age, sex, race, smoking, insurance type, BMI, self and family history of CVD, initial troponin, antidiabetic medication, anticoagulant medication, anti-hyperlipidemia medication, anti-hypertension medication, and Elixhauser comorbidities