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. 2022 Feb 23;10:833938. doi: 10.3389/fcell.2022.833938

FIGURE 2.

FIGURE 2

HSPA6 may be a poor prognostic and predictive biomarker for patients with glioma. (A) A core gene map for the HSP70 family network was constructed by using Cytoscape. Increasing red coloration indicates a stronger core. (B) A PPI network for HSPA6 was constructed by Cytoscape. (C,E) Kaplan‒Meier overall survival (OS) and progression free survival (PFS) curves for glioma patients in accordance with HSPA6 expression in The Cancer Genome Atlas (TCGA) cohort. (D,F) Time-dependent receiver operating characteristic curves for the prognostic model in the TCGA cohort (for predicting 1-, 3-, and 5-year overall OS and PFS). (G) Variance analysis of HSPA6 expression with regards to various clinical traits [IDH, 1p/19q, grade, gender and age] in the TCGA cohort. (H) Relationship between HSPA6 expression and the clinical features of gliomas. ***p < 0.001. (I) Univariate and multivariate cox regression analyses based on clinical features (HSPA6, age, gender, grade, 1p/19q and IDH) in the TCGA cohort (p < 0.05). Risk factor: hazard ratio (HR)>1; protective factor: HR < 1.