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. 2022 Feb 23;10:833938. doi: 10.3389/fcell.2022.833938

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Copyright © 2022 Zhou, Ji, Li, Wang, Hu, Xiao, Ye, Lin, Luo, Guo, Wu, Huang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional annotation of subgroups with high and low expression levels of HSPA6. (A) Differentially expressed genes (DEGs) between the subgroups of patients with low and high HSPA6 expression were identified by the Wilcoxon rank sum test in the TCGA cohort (FDR < 0.05 and log2Fold Change >1) cohort. (B,C) GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis for DEGs (p < 0.05 and q < 0.05). There were 1669 DEGs in the TCGA cohort. (D) GSVA (Gene Set Variation Analysis) in the TCGA cohort, Chinese Glioma Genome Atlas (CGGA) cohort, and GSE16011 cohort, as determined by Gene Expression Omnibus (red = high score, blue = low score).