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. 2022 Feb 23;10:833938. doi: 10.3389/fcell.2022.833938

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Copyright © 2022 Zhou, Ji, Li, Wang, Hu, Xiao, Ye, Lin, Luo, Guo, Wu, Huang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different tumor microenvironment (TME) characteristics of the two subgroups in the TCGA cohort. (A–C) Correlations of HSPA6 expression with 29 immune-associated gene sets, immune score, stromal score, ESTIMATE score, and tumor purity. (D) Different abundances of TIICs when compared between subgroups of patients with low and high expression levels of HSPA6. (E) Differential analysis of several immune checkpoint (ICP) expression levels between patients with low and high HSPA6 expression levels. (F) Differential expression of different immune checkpoint receptors and ligands between the two subgroups. Correlation analysis was performed by Pearson’s correlation analysis. ns, p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.