TABLE 2.

Safety profile of trabectedin (NCI-CTC Grade3 or 4 toxicity).

	Demetri et al. (2016)	Le Cesne et al. (2013)
Adverse events	n = 340 (%)	n = 350 (%)
Neutropenia	37	47.6
ALT elevation	26	44.6
Thrombocytopenia	17	13.5
Anemia	14	12.3
AST elevation	13	34.4
Fatigue	6	8.3
CPK elevation	5.3	4.1
Nausea	5	6.3
Vomiting	5	5.1
Rhabdomyolysis	1.2

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CPK, creatine phosphokinase; NCI-CTC, National Cancer Institute Common Toxicity Criteria.