TABLE 3.

Univariate and multivariate cox regression analysis of overall survival.

Characteristics	Univariate cox analysis		Multivariate cox analysis
	Hazard ratio (95%CI)	p value	Hazard ratio (95%CI)	p value
Age (year)
≤50	Reference		Reference
>50	2.103 (1.199–3.689)	0.010*	1.770 (0.640–4.900)	0.272
BMI
≤23	Reference
>23	0.810 (0.463–1.416)	0.460
Menstrual status
Premenopausal	Reference		Reference
Postmenopausal	1.859 (1.067–3.238)	0.029*	0.910 (0.320–2.570)	0.852
Histological grade a
1/2	Reference
3	1.235 (0.701–2.176)	0.464
Lymphovascular invasion
No	Reference		Reference
Yes	2.689 (1.504–4.809)	0.001*	1.820 (0.920–3.600)	0.086
Ki-67 index at diagnosis < 30% b
No	Reference
Yes	0.891 (0.456–1.740)	0.735
T stage c
1	Reference		Reference
2	0.880 (0.473–1.638)	0.686	0.820 (0.430–1.540)	0.535
3	1.363 (0.537–3.458)	0.514	1.020 (0.370–2.870)	0.963
4	5.251 (1.536–17.958)	0.008*	3.880 (1.070–13.990)	0.039*
N stage c
0	Reference		Reference
1	2.099 (1.002–4.397)	0.049*	1.990 (0.930–4.280)	0.077
2	3.640 (1.621–8.174)	0.002*	2.990 (1.260–7.060)	0.013*
3	7.134 (3.392–15.006)	<0.001*	4.510 (1.940–10.500)	<0.001*
IronMLR score
Low	Reference		Reference
High	2.404 (1.201–4.808)	0.013*	2.730 (1.310–5.710)	0.008*

*p＜0.05.

^aHistological grade at diagnosis was based on the degree of histological tumor differentiation.

^bThe Ki-67 index at diagnosis indicates DNA synthetic activity as measured using immunocytochemistry.

^cDiagnosed based on the AJCC 2010 criteria (seventh edition).