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. 2022 Feb 23;12:839899. doi: 10.3389/fonc.2022.839899

Table 2.

Univariate cox proportional hazard analysis for risk factors of patients’ prognosis.

Characteristics OS DFS
HR (95%CI) P value HR (95%CI) P value
Gender Male 1.0 (ref) P<0.001 1.0 (ref) P<0.001
Female 0.51 (0.41,0.64) 0.59 (0.49,0.71)
Diabetes mellitus No 1.0 (ref) P=0.776 1.0 (ref) P=0.604
Yes 0.96 (0.71,1.30) 0.93 (0.72,1.21)
Hypertension
(≥130/85mmHg)
No 1.0 (ref) P=0.377 1.0 (ref) P=0.592
Yes 0.9 (0.72,1.13) 0.95 (0.78,1.15)
Anemia No 1.0 (ref) P=0.565 1.0 (ref) P=0.638
Yes 1.07 (0.85,1.36) 1.05 (0.86,1.29)
Ileus No 1.0 (ref) P=0.012 1.0 (ref) P=0.118
Yes 1.41 (1.08,1.86) 1.22 (0.95,1.55)
Primary site Multiple primary 1.0 (ref) P=0.296 1.0 (ref) P=0.265
Right-sided colon 1.16 (0.16,8.31) 0.68 (0.17,2.73)
Left-sided colon 0.99 (0.14,7.06) 0.63 (0.16.2.56)
Rectum 0.93 (0.13,6.61) 0.56 (0.14,2.27)
Tumor size <5cm 1.0 (ref) P<0.001 1.0 (ref) P<0.001
≥5cm 2.77 (2.25,3.41) 2.09 (1.76,2.47)
T stage T1 1.0 (ref) P<0.001 1.0 (ref) P<0.001
T2 1.14 (0.42,3.09) 1.13 (0.56,2.28)
T3 2.00 (0.82,4.88) 1.22 (0.65,2.31)
T4 2.89 (1.19,6.99) 1.84 (0.98,3.45)
N stage N0 1.0 (ref) P<0.001 1.0 (ref) P<0.001
N1 1.89 (1.50,2.37) 2.12 (1.75,2.56)
N2 2.76 (2.17,3.50) 2.67 (2.16,3.30)
Metastasis M0 1.0 (ref) P<0.001 1.0 (ref) P<0.001
M1 5.57 (4.42,7.03) 6.95 (5.61,8.62)
Adjuvant therapy No 1.0 (ref) P<0.001 1.0 (ref) P<0.001
Yes 0.20 (0.16,0.22) 0.40 (0.34,0.48)
Age 1.00 (0.99,1.01) P=0.839 1.00 (0.99,1.01) P=0.592
BMI 0.99 (0.97,1.02) P=0.665 1.00 (0.97,1.02) P=0.757
MA (Muscle attenuation) 0.92 (0.91,0.93) P<0.001 0.94 (0.93,0.94) P<0.001
IMF (intermuscular) 0.99 (0.97,1.01) P=0.355 1.00 (0.98,1.02) P=0.904
TPA 1.00 (0.99,1.01) P=0.720 1.00 (0.99,1.01) P=0.755
TAMA 0.93 (0.93,0.94) P<0.001 0.95 (0.95,0.96) P<0.001
VFA 1.00 (1.00,1.01) P=0.054 1.00 (1.00,1.01) P=0.001
PFA 0.97 (0.95,0.98) P<0.001 0.98 (0.97,0.99) P<0.001
SFA 1.00 (1.00,1.01) P=0.880 1.00 (0.99,1.00) P=0.962
Abdominal wall fat thickness 1.05 (0.96,1.15) P=0.268 1.04 (0.96,1.12) P=0.322
PPNF 1.00 (0.93,1.09) P=0.922 1.02 (0.95,1.09) P=0.603
VD (visceral fat density) 1.00 (0.99,1.01) P=0.924 1.00 (1.00,1.01) P=0.647
SD (subcutaneous fat density) 1.00 (1.00,1.01) P=0.609 1.00 (0.99,1.00) P=0.606
PMI 0.96 (0.92,0.99) P=0.009 0.99 (0.96,1.02) P=0.054
LSMI (linear skeletal muscle index) 0.78 (0.76,0.79) P<0.001 0.82 (0.81,0.83) P<0.001
SMI 0.80 (0.78,0.81) P<0.001 0.85 (0.84,0.86) P<0.001