TABLE 2.
RNAseq pathway enrichment results.
| SCZ-NR vs. Ctrl | SCZ-R vs. Ctrl | SCZ-R (+CLZ) vs. SCZ-R (−CLZ) | SCZ-NR vs. Ctrl | SCZ-R vs. Ctrl | SCZ-R (+CLZ) vs. SCZ-R (−CLZ) | SCZ-NR vs. SCZ-R | SCZ-NR vs. SCZ-R |
| Down-regulated genes in SCZ-NR | Down-regulated genes in SCZ-R | Up-regulated genes in SCZ-R (+CLZ) | Up-regulated genes in SCZ-NR | Up-regulated genes in SCZ-R | Down-regulated genes in SCZ-R (+CLZ) | Up-regulated genes in SCZ-NR | Down-regulated genes in SCZ-NR |
| 1. Viral carcinogenesis | 1. Synaptic vesicle cycle | 1. VEGF signalling pathway | 1. TGF-beta signalling pathway | 2. TGF-beta signalling pathway | 4. TGF-beta signalling pathway | 1. Synaptic vesicle cycle | 1. Wnt signalling pathway |
| 2. Transcriptional misregulation in cancer | 2. Pancreatic secretion | 3. Rap1 signalling pathway | 2. Renal cell carcinoma | 3. Signalling pathways regulating pluripotency of stem cells | 1. Viral carcinogenesis | 2. Salivary secretion | 2. Viral carcinogenesis |
| 3. Systemic lupus erythematosus | 3. Retrograde endocannabinoid signalling | 2. Retrograde endocannabinoid signalling | 3. Regulation of actin cytoskeleton | 4. Regulation of actin cytoskeleton | 2. Transcriptional misregulation in cancer | 3. Retrograde endocannabinoid signalling | 3. Tyrosine metabolism |
| 4. Small cell lung cancer | 4. Proximal tubule bicarbonate reclamation | 4. Proximal tubule bicarbonate reclamation | 4. Proteoglycans in cancer | 5. Proteoglycans in cancer | 5. Systemic lupus erythematosus | 4. Pancreatic secretion | 4. Transcriptional misregulation in cancer |
| 5. Ribosome | 2. Ribosome | 5. Oxytocin signalling pathway | 5. Prostate cancer | 6. Platelet activation | 6. Small cell lung cancer | 5. Oxytocin signalling pathway | 5. TGF-beta signalling pathway |
| 6. Proteasome | 6. Morphine addiction | 7. Morphine addiction | 6. PI3K-Akt signalling pathway | 7. PI3K-Akt signalling pathway | 3. Thyroid cancer | 6. Morphine addiction | 6. Systemic lupus erythematosus |
| 7. Pathways in cancer | 12. GABAergic synapse | 13. GABAergic synapse | 7. Pathways in cancer | 8. Pathways in cancer | 7. Pathways in cancer | 7. Melanogenesis | 7. Signalling pathways regulating pluripotency of stem cells |
| 8. Parkinson’s disease | 8. Insulin secretion | 9. Insulin secretion | 8. Malaria | 1. Tight junction | 8. Mismatch repair | 8. Long-term potentiation | 8. Pentose phosphate pathway |
| 9. p53 signalling pathway | 14. Dopaminergic synapse | 15. Dopaminergic synapse | 9. Hypertrophic cardiomyopathy (HCM) | 9. Hypertrophic cardiomyopathy (HCM) | 10. Hypertrophic cardiomyopathy (HCM) | 9. Insulin secretion | 9. Pathways in cancer |
| 10. Oxidative phosphorylation | 15. Cholinergic synapse | 8. Long-term potentiation | 10. HTLV-1 infection | 10. HTLV-1 infection | 11. HTLV-1 infection | 10. GnRH signalling pathway | 10. Melanogenesis |
| 11. Non-alcoholic fatty liver disease (NAFLD) | 11. Gastric acid secretion | 12. Gastric acid secretion | 11. Glycosphingolipid biosynthesis-lacto and neolacto series | 11. Hippo signalling pathway | 12. Hippo signalling pathway | 11. Gastric acid secretion | 11. Hypertrophic cardiomyopathy |
| 12. Melanogenesis | 7. Melanogenesis | 6. Nicotine addiction | 12. Gastric acid secretion | 17. Complement and coagulaion cascades | 9. Melanogenesis | 12. GABAergic synapse | 12. HTLV-1 infection |
| 13. Hippo signalling pathway | 9. Hippo signalling pathway | 16. Cocaine addiction | 13. Glioma | 18. Cell cycle | 18. Cell cycle | 13. ErbB signalling pathway | 13. Hippo signalling pathway |
| 14. Hedgehog signalling pathway | 10. Hedgehog signalling pathway | 10. HIF-1 signalling pathway | 14. Gap junction | 14. DNA replication | 16. DNA replication | 14. Circadian entrainment | 14. Falconic anemia pathway |
| 15. ECM-receptor interaction | 13. Endocytosis | 14. Endocytosis | 15. Focal adhesion | 12. Focal adhesion | 13. Focal adhesion | 15. Cholinergic synapse | 15. ECM-receptor interaction |
| 16. Cardiac muscle contraction | 16. Glutamatergic synapses/cAMP signalling pathway | 11. Glutamatergic synapses | 16. ECM-receptor interaction | 13. ECM-receptor interaction | 14. ECM-receptor interaction | 16. Calcium signalling pathway | 16. Cell cycle |
| 17. Basal cell carcinoma | 18. Basal cell carcinoma | 17. Circadian entrainment | 17. Dorso-ventral axis formation | 16. Cytokine-cytokine receptor interaction | 17. Colorectal cancer | 17. Bile secretion | 17. Basal cell carcinoma |
| 18. Axon guidance | 19. Axon guidance | 18. Axon guidance | 18. Dilated cardiomyopathy | 15. Dilated cardiomyopathy | 16. Dilated cardiomyopathy | 18. Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 18. DNA replication |
| 19. Aldosterone-regulated sodium reabsorption | 17. Bile Secretion | 19. Amphetamine addiction | 19. Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 19. Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 19. Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 19. Amphetamine addiction | 19. Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| 20. Alcoholism | 20. Adrenergic signaling in cardiomyocytes | 20. ABC transporters | 20. Amoebiasis | 20. Amoebiasis | 20. Alcoholism | 20. Adrenergic signaling in cardiomyocytes | 20. Alcoholism |